Welcome to the Maine Lab in the Department of Biology at Syracuse University
We study the regulation of cell fate during animal development, focusing on germline development in the model organism, Caenorhabditis elegans. We use a variety of genetic, molecular, genomics, biochemical, and cell biological approaches to study mechanisms that regulate germ cell proliferation and gamete formation.
Our areas of research include:
- Regulation of chromatin structure during meiosis
- Balancing germ cell renewal and differentiation
The Maine Lab works to understand how histone modifications are targeted to specific chromosomal sites, along with the role of meiotic silencing in Caenorhabditis elegans. We have identified a number of regulators of germline proliferation, including positive regulators of GLP-1/Notch signaling. We also study how diverse regulatory pathways are controlled to maintain a balance between germ cell renewal and gamete formation.